Can trihexyphenidyl be stopped abruptly?
Do not stop taking trihexyphenidyl abruptly. You can have a quick return of your symptoms and possibly develop a life-threatening condition called neuroleptic malignant syndrome.
Does trihexyphenidyl cause euphoria?
Trihexyphenidyl also produces a short-acting euphoric and mood-elevating effect, which is why it is a drug of potential misuse. There have been cases of the disruption of normal sleep architecture (REM sleep depression).
How do you wean off trihexyphenidyl?
In general, wean gradually by 25% of the daily dose every 1-4 weeks. If reason for deprescribing is due to serious adverse effects, consider weaning faster. Provide advice to patient/carer on self-monitoring and what to do if symptoms re-occur.
What happens when you stop taking trihexyphenidyl?
Do not stop taking trihexyphenidyl suddenly without talking with your doctor, especially if you are also taking other medications. Sudden stoppage can cause symptoms of Parkinson’s disease to return.
Can you get high from trihexyphenidyl?
Trihexyphenidyl has been reported to be abused by some patients, who start to take it in increasing doses and tend to report a sensation of relaxation or pleasure with this medication.
Does trihexyphenidyl cross the blood brain barrier?
We conducted a randomized, double-blind, crossover trial of two anticholinergic agents–trihexyphenidyl and tridihexethyl chloride (a quaternary anticholinergic that does not cross the blood-brain barrier)–in patients with acquired nystagmus and measured visual acuity and nystagmus before and at the end of 1 month on …
What are the side effects of trihexyphenidyl?
Trihexyphenidyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness or blurred vision.
- dry mouth.
- upset stomach.
- difficulty urinating.
What should I know about trihexyphenidyl before taking it?
If trihexyphenidyl causes your mouth to feel dry, you may need to take it before meals. You may also use mints, chewing gum, or water if you have a very dry mouth or you feel very thirsty. The pressure inside your eyes will need to be checked while you are taking trihexyphenidyl.
What class of drug is trihexyphenidyl?
Trihexyphenidyl belongs to a class of drugs called anticholinergics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Trihexyphenidyl works by blocking the function of a certain part of your nervous system that regulates body movements.
What is the mechanism of action of Trihexyphenidyl?
Although the precise mechanism of action of trihexyphenidyl remains poorly understood, it appears to act on the parasympathetic nervous system by inhibiting the efferent impulses directly.
What are the limitations of Trihexyphenidyl in the treatment of parkinsonism?
Clinicians should avoid abrupt withdrawal of trihexyphenidyl in patients undergoing treatment for parkinsonism symptoms, as this could cause an acute exacerbation of existing symptoms. There are reports of neuroleptic malignant syndrome in patients who had an abrupt withdrawal of treatment.