How is Sodium Pentothal administered?

Pentothal (thiopental sodium) is administered by the intravenous route only. Individual response to the drug is so varied that there can be no fixed dosage. The drug should be titrated against patient requirements as governed by age, sex and body weight.

How do you dilute Thiopentone sodium?

Sodium thiopentone (also known as thiopental or pentothal) is prepared by dissolving a yellowish powder in sterile water to provide a 2.5% solution (ie 25mg/ml). In this concentration 20mls of solution will contain 500mg. The solution should be used within 24 hours of preparation and kept cool.

Why is thiopental short acting?

As with all lipid-soluble anaesthetic drugs, the short duration of action of sodium thiopental is due almost entirely to its redistribution away from central circulation into muscle and fatty tissue, due to its very high lipid–water partition coefficient (approximately 10), leading to sequestration in fatty tissue.

What class of drug is thiopental?

Thiopental is a DEA Schedule III controlled substance. Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.

What is the pH of Thiopentone?

During induction of anesthesia, this phenomenon may be encountered when a basic drug such as thiopental (pH 8.5-10.5) remains in the intravenous (IV) tubing at the time of injection of acidic drugs such as some of the muscle relaxants.

How is thiopental metabolism?

Thiopental is extensively metabolized, primarily in the liver, resulting in only 0.3% of an administered dose being excreted unchanged in the urine. Ring desulfuration leads to the generation of an active metabolite, pentobarbital, that exists in concentrations approximately 3-10% that of the parent concentration.

Is thiopental water soluble?

The free acid (thiopental) melts at 158–160˚C. At 20˚C, thiopental sodium is soluble in 1.5 parts of water. It is partially soluble in alcohol and is practically insoluble in ether, benzene, and petroleum ether.

What is pentothal for injection?

Pentothal for Injection is a yellowish powder available as 500 mg vials in packs of 25 and 50*. *not all pack sizes are marketed. Pentothal for Injection contains 500 mg of thiopental sodium as the active ingredient.

How much pentothal do you give for a test?

Test Dose. It is advisable to inject a small “test” dose of 25 to 75 mg (1 to 3 mL of a 2.5% solution) of Pentothal (Thiopental Sodium for Injection) to assess tolerance or unusual sensitivity to Pentothal, and pausing to observe patient reaction for at least 60 seconds.

How much Pentothal is required for rapid induction of thiopental sodium (THP)?

As an initial dose, 210 to 280 mg (3 to 4 mg/kg) of Pentothal (thiopental sodium) is usually required for rapid induction in the average adult (70 kg).

What are the diluents used in the preparation of a pentothal solution?

Pentothal (Thiopental Sodium for Injection, USP) is supplied as a yellowish, hygroscopic powder in a variety of different containers. Solutions should be prepared aseptically with one of the three following diluents: Sterile Water for Injection, USP, 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP.