What antihypertensive is safe in pregnancy?

What antihypertensive is safe in pregnancy?

The drugs most commonly used—methyldopa, labetalol, and nifedipine—are widely accepted as safe in pregnancy, based on many years of experience, observational data from large databases, and meta‐analyses of multiple small clinical trials.

Are vasodilators safe in pregnancy?

Oral hydralazine, a direct vasodilator, is effective as monotherapy or as add-on therapy to methyldopa in the long term management of chronic hypertension in pregnancy. Hydralazine appears to be reasonably safe for the fetus although a few cases of fetal thrombocytopenia have been reported.

Which antihypertensive agent is contraindicated in pregnancy?

Both labetalol and methyldopa are considered safe for use in pregnant women,12,13 while angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB) are contraindicated during all trimesters of pregnancy based on their potential teratogenic and fetotoxic effects,1 though this is …

What is first-line agent for hypertension in pregnancy?

Background: Hydralazine, labetalol, and nifedipine are the recommended first-line treatments for severe hypertension in pregnancy.

Is losartan safe in pregnancy?

Tell your doctor if you are pregnant or plan to become pregnant. Do not take losartan if you are pregnant. If you become pregnant while you are taking losartan, stop taking losartan and call your doctor immediately. Losartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy.

Is Norvasc safe in pregnancy?

Norvasc and Pregnancy Norvasc falls into category C. There are no good studies in pregnant women. Norvasc should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if Norvasc will harm your unborn baby.

Can labetalol cause birth defects?

Use of labetalol in pregnancy is common and there is no concern that it causes harm. Labetalol belongs to a family of medicines called beta blockers. Studies have not shown that beta blockers cause birth defects, stillbirth, or preterm birth. Women taking beta blockers may be more likely to have a small baby.

How do you control gestational hypertension?

Some ways you can help prevent gestational hypertension include the following:

  1. Use salt as needed for taste.
  2. Drink at least 8 glasses of water a day.
  3. Increase the amount of protein you take in, and decrease the number of fried foods and junk food you eat.
  4. Get enough rest.
  5. Exercise regularly.

Which drug is contra indicated in pregnancy?

Ibuprofen (Motrin, Advil) Herbs, minerals, amino acids, and regular vitamins. Isotretinoin (formerly sold as Accutane, now Absorica, Amnesteem, Claravis, Myorisan, Zenatane) taken for acne. Thalidomide (Thalomid) taken for a type of skin disease and multiple myeloma.

Is atenolol contraindicated in pregnancy?

It is concluded that atenolol and labetalol are safe and they are usually effective in the control of the hypertension complicating pregnancy.

Can I take amlodipine while pregnant?

Amlodipine can be used in pregnancy. Although there is not a lot of information on its safety, it is not thought to be harmful to the baby. If you are pregnant, or planning a pregnancy, talk to your doctor about it. They may wish to change amlodipine for a medicine that has more safety information.

What is the best drug for high blood pressure in pregnancy?

Drug treatment of hypertension in pregnancy According to NHBPEP methyldopa, labetalol, beta blockers (other than atenolol), slow release nifedipine, and a diuretic in pre-existing hypertension are considered as appropriate treatment [1].

What are direct vasodilators used for?

Direct vasodilators are strong medications that generally are used only when other medications haven’t controlled blood pressure adequately. These medications have a number of side effects, some of which require taking other medications to treat. Types of blood pressure medications.

How does pregnancy affect the pharmacokinetics of cardiovascular medications?

Several hemodynamic and physiologic adaptations occur during pregnancy and the pharmacokinetics of cardiovascular medications can change throughout gestation. Data on medication safety are often drawn from observational studies and expert opinion.

Which medications are contraindicated during pregnancy for afterload reduction?

During pregnancy, hydralazine plus nitrates can be used for afterload reduction (angiotensin-converting enzyme [ACE] inhibitors are contraindicated). ACE inhibitors, angiotensin-receptor blockers, direct renin-inhibitors, angiotensin receptor-neprysilin inhibitors, spironolactone, and eplerenone are contraindicated.