What are the most common side effects of antimetabolite treatments?

What are the most common side effects of antimetabolite treatments?

In general, side effects found in many antimetabolites include:

  • Nausea, vomiting, or loss of appetite.
  • Tiredness, weakness, or sore muscles.
  • A headache and dizziness.
  • Inflammation of the mouth and lips.
  • Higher levels of liver enzymes, which can be a sign of inflamed or injured liver cells.
  • Hair loss.

What do antimetabolites affect?

Antimetabolites interfere with DNA and RNA synthesis by acting as false metabolites, which are incorporated into the DNA strand or block essential enzymes, so that DNA synthesis is prevented.

How do antimetabolites affect cancer cells?

Antimetabolites are a group of chemotherapy drugs that mimic molecules that cancer cells need to create their DNA. When cancer cells use antimetabolites in their DNA, the drugs interfere with their ability to replicate properly. Then the cancer cells die. Antimetabolites are effective at treating many types of cancer.

How do antimetabolite chemotherapy drugs exert their cytotoxic effect?

Antimetabolites. Antimetabolites are group of anticancer agents that exert their cytotoxic effects by interfering with the DNA synthesis. Some of the important drugs from this class are 5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza.

Which drugs are antimetabolites?

Included are folic acid antagonists, such as methotrexate; purine antimetabolites, such as 6-mercaptopurine, 6-thioguanine, fludarabine phosphate, pentostatin, and cladribine; and the pyrimidine antimetabolites such as 5-fluorouracil, 5-fluorodeoxyuridine, cytarabine, and gemcitabine.

Which of the following is a antimetabolite?

Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®)

What are antimetabolite agents?

Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid).

What are antimetabolites agents?

Antimetabolites are group of anticancer agents that exert their cytotoxic effects by interfering with the DNA synthesis. Some of the important drugs from this class are 5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza.

What are antimetabolite medications?

Which group is an antimetabolite?

What are antimetabolites in chemotherapy?

Antimetabolites are chemotherapy drugs that are used to kill cancer (malignant) cells. Antimetabolites are drugs that may be similar in structure to substances that are essential for growth and division of both normal and cancerous cells or may combine with enzymes to interfere with normal metabolic processes within cells.

What are the side effects of antimetabolites?

Like all types of chemotherapy, they can cause damage to healthy cells that leads to side effects like nausea, vomiting, and hair loss. If you or your loved one has cancer, your doctor may recommend taking antimetabolites or other forms of chemotherapy.

How do antimetabolites affect DNA synthesis?

Print Share. Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid).

Is gemcitabine a chemotherapy drug?

Gemcitabine is a chemotherapy drug that is classified as an antimetabolite. It is used to treat non-small cell lung cancer (NSCLC), pancreatic cancer, bladder cancer, soft-tissue sarcoma, metastatic breast cancer, and ovarian cancer. Gemcitabine may cause side effects.