What is interferon gamma therapy used for?

Interferon gamma-1b injection is used to reduce the frequency and severity of serious infections in people with chronic granulomatous disease (an inherited immune system disease). It is also used to slow down worsening of their condition in people with severe, malignant osteopetrosis (an inherited bone disease).

How much does interferon gamma cost?

Interferon gamma, used in chronic granulomatous disease, costs about $140 for a 100-microg vial; yearly costs average $21840 per patient.

How is interferon gamma administered?

ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.

What inhibits interferon gamma?

We demonstrate that type 1 interferons not only fail to induce, but also act to inhibit, IFN-γ expression by both NK and T cells. The mechanism of inhibition is dependent upon the IFN-α/β receptor and the signal transducer and activator of transcription 1 (STAT1).

How do interferons work?

Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they “interfere” with viruses and keep them from multiplying.

Where does interferon-gamma come from?

IFN-γ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response.

Who manufactures actimmune?

Visit www.ACTIMMUNE.com to download a copy of the ACTIMMUNE Full Prescribing Information. Horizon Pharma plc is a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.

Who makes actimmune?

Actimmune is made available by Horizon Pharma, Inc., through one or more subsidiaries and affiliates, (collectively, “Horizon”) to Canadian patients under the Health Canada Special Access Programme (“SAP”).

What is interferon beta-1b?

Interferon beta-1b injection is used to treat the relapsing-remitting forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

What is interferon gamma-1b used to treat?

It is also used to slow down worsening of their condition in people with severe, malignant osteopetrosis (an inherited bone disease). Interferon gamma-1b is in a class of medications called immunomodulators.

What are the side effects of interferon gamma-1b?

Interferon gamma-1b side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Does interferon gamma-1b need to be refrigerated?

Store interferon gamma-1b in the refrigerator, do not freeze. You may take the medicine out of the refrigerator and allow it to reach room temperature before injecting your dose. Do not leave the medicine at room temperature for longer than 12 hours. Throw the medicine if it has been at room temperature for more than 12 hours.

What happens if you drink alcohol while taking interferon gamma-1b?

Drinking alcohol with interferon gamma-1b can cause side effects. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.