What is the difference between Sprague Dawley and Wistar rats?

Wistar Rats – Long ears, tail length shorter than body length and wider head. Sprague Dawley Rats – Longer and Narrower head, tail longer than body (may equal to body length). SD grows faster than Wistar rats (eg: SD rats gain 400 g BW by 12 weeks and Wistar rats gains~350 g BW).

What animals are used at Charles River Laboratories?

Charles River is committed to providing you with high-quality animal models, including mice, rats, guinea pigs, hamsters, gerbils, and rabbits. We also offer study-ready knockout mouse models for in vivo studies through our collaboration with genOway.

Does Charles River do animal testing?

Charles River conduct painful, live experiments on animals for the Pharmaceutical, Animal Health, Medical Device, Biotechnology and Food Industries. They are a contract testing business, which means they will test anything, on any animal, for a price.

Are Sprague Dawley rats outbred?

The Sprague Dawley® (SD) rat is one of the most popular outbred stocks, with application across many therapeutic areas as well as ADMET studies. The SD is an outbred stock, meaning that there is genetic variation within the stock, and each individual varies in genetic makeup.

Why do we use Sprague Dawley?

The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Its main advantage is its calmness and ease of handling. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin.

How much are lab mice?

These animals, which are often used in studies involving genetic modifications, are costly to purchase – between $47 and $128 each.

Are Wistar rats inbred?

Genetic Transmission and Chromosomal Mapping WAG/Rij are fully inbred rats, which means that they are homozygous for all autosomal genes. All individuals display SWDs on their EEG. In the initial colonies of Wistar rats in Strasbourg, 30% of the animals showed spontaneous SWDs.

What does outbred rat mean?

Outbred Stocks Outbred rat stocks are genetically diverse within the population, and there is likely genetic variability between any two animals within the population. Outbred stocks are primarily used in studies designed to evaluate or model the human population.

What is the history of the Sprague Dawley rat?

The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. The rats are maintained as an outbred closed colony. Taconic received stock from the NIH Animal Genetic Resource in 1970.

Where can I find more information about the Charles River Rat?

For additional information, please visit the CD rat page on the Charles River Japan website. Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat.

What is the specific gravity of line Sprague Dawley rats?

Specific Gravity 1.0195 ± 0.0068 1.0155 ± 0.0079 Phenotyping Procedures: Animal Receipt and Maintenance A quantity of twenty rats (ten males and ten females) was submitted for testing, strain identified as Line Sprague Dawley® (NTac:SD), age 7 weeks.

What is the Sprague Dawley® outbred model?

The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. The rats are maintained as an outbred closed colony.