What is the mechanism of action of indapamide?

What is the mechanism of action of indapamide?

Indapamide has a dual mechanism of action: diuretic effect at the level of the distal tubule in the kidney and a direct vascular effect, both of which contribute to the antihypertensive efficacy of the drug.

What type of diuretic is indapamide?

Indapamide is a thiazide-like diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

What is Lozide?

This medication is a diuretic (water pill). Typically, it is used to lower blood pressure. Even though you may not feel its effects, this medication takes effect after a few weeks.

How does a thiazide diuretic work?

Thiazide diuretics are drugs that cause both natriuresis (removal of sodium in the urine) and diuresis. Thiazide diuretics work by blocking sodium and chloride (Na/Cl) channels in the distal convoluted tubule of the nephron and inhibit the reabsorption of sodium and water.

Does indapamide cause thrombocytopenia?

These reactions were reversible with discontinuance of the drug. Also reported are erythema multiforme, Stevens-Johnson Syndrome, bullous eruptions, purpura, photosensitivity, fever, pneumonitis, anaphylactic reactions, agranulocytosis, leukopenia, thrombocytopenia, and aplastic anemia.

Does indapamide cause hyponatremia?

Conclusions: Indapamide can cause both severe hypokalemia and hyponatremia. The predominant clinical features can be a result of severe hyponatremia. The latter can have diverse clinical presentations and may be mistaken for SIADH.

Is indapamide a loop diuretic?

Thiazides, Loop Diuretics, and Potassium-Sparing Drugs Thiazides include hydrochlorothiazide, chlorthalidone, metolazone, indapamide. Examples of loop diuretics are furosemide and bumetanide. K+-sparing drugs are spironolactone, triamterene, and amiloride.

What is the generic name for Lozide?

Indapamide belongs to the family of medications called diuretics (“water pills”). It is used alone or in combination with other medications to treat mild-to-moderate high blood pressure.

How do thiazide diuretics work in hypertension?

Thiazide diuretics are used to treat high blood pressure by reducing the amount of sodium and water in the body. Thiazides are the only type of diuretic that dilates (widens) the blood vessels, which also helps to lower blood pressure.