Where is the space of Disse located?

The Space of Disse, D, located between the sinusoid endothelial cells (S) and the hepatocytes (on the left of the micrograph), is continuous with the sinusoidal lumen. Numerous irregular microvilli, Mv, extend from the hepatocyte surface into the space of Disse, increasing the surface area for metabolic exchange.

Which cell is located in the space of Disse?

The Disse space contains stellate cells, also called Ito cells or lipocytes; these cells contain lipids and are involved in vitamin A metabolism. They are not normally visible on H&E section but can be visualized on methylene blue–stained 1-μm thin sections for electron microscopy (Fig. 1-22).

What is the location of hepatocyte cell?

the liver
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis.

What is space of Disse in histology of liver?

The space between sinusoidal endothelium and hepatocytes is called the space of Disse. Sinusoidal endothelial cells are highly fenestrated, which allows virtually unimpeded flow of plasma from sinusoidal blood into the space of Disse.

What is Portal lobule?

portal lobule a polygonal mass of liver tissue containing portions of three adjacent hepatic lobules, and having a portal vein at its center and a central vein peripherally at each corner. primary lobule of lung (primary respiratory lobule) the functional unit of the lung; terminal respiratory unit.

Why is space of Disse important?

Disse space encloses a low density basal membrane similar to matrix and this membrane is essential for the maintenance of the function of the pored parenchymal cells that conduct metabolic exchange between the blood flow and hepatocytes.

What is Ito cell?

Ito cells (perisinusoidal fat-storing cells, stellate cells, lipocytes) of the liver are mesenchymal cells located in the space of Disse. They are the main place of vitamin A storage in characteristic lipid droplets.

Where does the space of Disse drain?

The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma….

What is space of mall?

The periportal space (Latin: spatium periportale), or periportal space of Mall, is a space between the stroma of the portal canal and the outermost hepatocytes in the hepatic lobule, and is thought to be one of the sites where lymph originates in the liver.

What is the sinusoid in the liver?

A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal …

How many lobules are there in liver?

The human liver is estimated to contain approximately 1 million classical hepatic lobules. Plates of hepatocytes are supported by reticulin and other stromal elements and appear to be radiating out from the central artery; blood and bile travel in opposite directions (Fig. 13.3).

What do hepatocytes look like?

Hepatocyte nuclei are distinctly round, with one or two prominent nucleoli. A majority of cells have a single nucleus, but binucleate cells are common. The micrographs below (H&E stain) demonstrate these features in sections of liver from a pig (left) and raccoon (right).