Which medication has the highest risk for nephrotoxicity?

What drugs are the biggest offenders?

• Antibiotics. Either alone or in combination, vancomycin and piperacillin/tazobactam are both commonly used antibiotics in critically ill children for broad coverage, but are known to have nephrotoxic potential.
• Aminoglycosides.
• Chemotherapy.
• NSAIDs.

Which antibiotic is most nephrotoxic?

Two antibiotics associated with nephrotoxicity that are used to treat dangerous resistant infections are vancomycin and colistin.

Which drug should not be given in renal disease?

Problematic drugs whose use in patients with renal insufficiency is nephrologically contraindicated: Pethidine, cefepime, lithium, gilbenclamide, gimepiride, metformin, spironolactone, eplerenone, methotrexate, gadolinium, enoxaparin.

Is paracetamol a nephrotoxic drug?

Paracetamol is a phenacetin metabolite (5). Phenacetin was considered one of the most nephrotoxic analgesics and has now been withdrawn from the market in most countries (6). A chronic nephrotoxic effect of therapeutic dosing of paracetamol is suggested by case-control studies (7–9⇓⇓).

Is furosemide nephrotoxic?

Impediment for loop diuretic use Furosemide can acidify the urine, and acidic urine may potentially result in formation of methemoglobin casts in patients with severe intravascular hemolysis [25], which are potentially nephrotoxic and may result in further renal impairment.

Is ciprofloxacin nephrotoxic?

Drug-induced nephrotoxicity is one of the leading causes of acute kidney injury worldwide. Nephrotoxicity of ciprofloxacin is often underestimated. In addition to causing acute kidney injury, chronic drug toxicity can in some cases lead to chronic kidney disease and eventually end-stage renal disease.

Is Rocephin nephrotoxic?

Although transient elevations of BUN and serum creatinine have been observed, at the recommended dosages, the nephrotoxic potential of Rocephin is similar to that of other cephalosporins. Ceftriaxone is excreted via both biliary and renal excretion (see CLINICAL PHARMACOL- OGY).

Is captopril nephrotoxic?

Alfuzosin may increase the hypotensive activities of Captopril. The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Captopril. The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Captopril.

Is metformin nephrotoxic?

Metformin itself is not a nephrotoxic drug. Initially appointed as the safest hypoglycemic agent in chronic kidney disease, its use has been limited in these patients because of the perceived risk of lactic acidosis.

Is Lasix ototoxic?

Some classes of diuretics, commonly called water pills, have ototoxic properties. These drugs include Lasix (furosemide) and Demadex (torsemide), and can cause ringing in the ears or hearing loss that usually goes away when the medication is discontinued. Aspirin.

Which antibiotics are nephrotoxic?

Pen VK: No dose alteration needed.

What are some commonly used nephrotoxic drugs?

• Drug-induced nephrotoxicity is an increasingly recognized complication of a wide variety of therapeutic agents. The nephrotoxicity of three of the most commonly used drug groups are reviewed in this article. They include antibiotics, radiocontrast agents, and nonsteroidal anti-inflammatory drugs.

What drugs are nephrotoxic?

– Angiotensin -converting enzyme inhibitors ( ACE Inhibitor s) – Angiotensin Receptor Blocker s (ARBs) – Cycosporine – Non-Steroidal Antiinflammatory drugs ( NSAID s) – Tacrolimus

Which antibiotic is not nephrotoxic?

Which antibiotic is not nephrotoxic? Pen VK: No dose alteration needed. 2)Amoxicillin: No dose adjustment. 3)Azithromycin: Avoid Azithromycin in patients with Liver disease. 4)Clindamycin: 5)Metronidazole (Flagyl) 6)Tetracycline HCL: Avoid Tetracycline HCL with Liver Disease. 7)Doxycycline: No dose