Which program can predict the pharmacokinetics parameters?
PKAnalyst for Windows. PKAnalyst for Windows provides the capability of simulation and parameter estimation for pharmacokinetic models.
What is DoseMeRx?
DoseMeRx is the world’s first and largest Bayesian dosing platform designed for clinical practice.
What is Bayesian dosing?
Bayesian dosing (also known as precision dosing) uses patient data and laboratory results to estimate a patient’s ability to absorb, process, and clear a drug from their system.
What is precision dosing?
Precision dosing is defined as the process of individualizing medication doses by taking into account patient-specific factors such as demographics, clinical characteristics, and genetic data.
What are pharmacokinetics parameters?
Pharmacokinetic parameters are assessed by monitoring variations in concentration of the drug and/or its metabolites in physiological fluids that are easy to access (i.e., plasma and urine). Plasma concentrations are usually checked, and in addition biopsies can be taken from animals and sometimes from humans.
What is Bayesian software?
Bayesian-guided AUC monitoring refers to using model-informed precision-dosing (MIPD) software to estimate and predict more accurate drug exposures over a period of time. It is based on Bayes’ Theorem, which can be used to update certain measures of interest based on prior knowledge and newly collected information.
How is dosing determined?
Prescription drug dosage is based typically on body weight. Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient’s body weight to determine a safe dosage.
Why is dosing important?
Dosing is particularly important for diseases and/or drugs where the drug can decrease severe morbidity or prolong life. Likewise, dosing is important where the drug can cause death or severe morbidity.
What is the example of pharmacokinetic parameter?
The pharmacokinetic characteristics can be quantitatively expressed by its parameters, such as the elimination rate constant (denoted as K), half-life (t 1/2), apparent volume of distribution (V d) and total clearance rate (CL).
What does the pharmacokinetics software do?
The pharmacokinetics software also lets you experiment with new approaches, such as integrating PK models with mechanistic or physiologically based PK models. You can import into SimBiology pharmacokinetics software PK and PD data of various sorts, including text files, Microsoft ® Excel ® files, and MATLAB files.
What is the pharmokinetic data analysis program?
The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.
How do I create a pharmacokinetics model?
SimBiology pharmacokinetics software allows you to create a PK model by specifying your desired model options in the PK model wizard. Model options include number of compartments, dosing type, and elimination route. Alternatively, you can create a PK or PD model using the graphical, tabular, or programmatic interfaces.
What is advanced pharmacokinetic information system?
by A. Iliadis and M. Laplane for model identification, simulation and dosage regimen calculation in clinical and experimental pharmacokinetics. APIS is based on mathematical modeling which provides a reliable approach in optimizing drug therapy. It is a methodological approach to describe, predict and control the kinetic behavior of a drug.