Which TB drug is most hepatotoxic?

Which TB drug is most hepatotoxic?

Among the first-line anti-TB drugs, isoniazid, rifampicin, and pyrazinamide are known to cause hepatotoxicity, but pyrazinamide attribute to a higher percentage for the drug induced liver toxicity compared to the other drugs.

Does INH cause elevated liver enzymes?

Severe liver injury is seen in up to 1% of the patients 2, 4. Elevations in ALT and AST can start as early as 1 week and sometimes as late as 9 months after starting treatment with INH. However, in more than half of the patients an ALT increase occurs between 1–6 months 2, 3, 5.

Is isoniazid metabolized in the liver?

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury.

Which is more hepatotoxic isoniazid or rifampin?

In a meta-analysis, isoniazid was more likely to be associated with hepatotoxicity (odds ratio (OR) 1.6) even in the absence of rifampicin, but the combination of these two drugs was associated with higher rate of hepatotoxicity (OR 2.6) when compared to each drug on its own.

Does isoniazid cause hepatitis?

Isoniazid (INH; isonicotinylhydrazide or isonicotinic acid hydrazine) is a synthetic antibiotic that is potently bactericidal against replicating Mycobacterium tuberculosis. INH has since been associated with two syndromes of hepatotoxicity: mild INH hepatotoxicity and INH hepatitis [1-3].

What is INH toxicity?

The ingestion of toxic amounts of isoniazid causes recurrent seizures, profound metabolic acidosis, coma and even death. In adults, toxicity can occur with the acute ingestion of as little as 1.5 g of isoniazid. Doses larger than 30 mg per kg often produce seizures.

What is isoniazid toxicity?

How does isoniazid cause neuropathy?

Conclusions: Isoniazid neuropathy develops in the presence of risk factors (HIV, alcoholism, diabetes, renal failure, malnutrition, pregnancy and lactation, neurotoxic medication) and manifests itself initially by burning feet. Pyridoxine is preventative in low dosage and curative in high dosage.

Can isoniazid cause liver damage?

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury.

Does age affect isoniazid pharmacokinetics and hepatotoxicity?

Drug Metabolism Reviews 01/2002; 34 (1-2):83-448.) Isoniazid is the first line treatment for tuberculosis however its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain.

Is isoniazid (INH) effective for tuberculosis?

This person is not on ResearchGate, or hasn’t claimed this research yet. Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure.

Is inh a hepatotoxic?

However, INH is also widely known for its hepatotoxicity and even liver failure risk 12,13 .