Why is atropine contraindicated in organochlorine poisoning?

Why is atropine contraindicated in organochlorine poisoning?

Because it does not significantly relieve depression of the respiratory center or decrease muscarinic effects of AChE poisoning, administer atropine concomitantly to block these effects of OP poisoning. Signs of atropinization might occur earlier with addition of 2-PAM to treatment regimen.

What is the effect of organochlorine in human body?

Organochlorines are known for their high persistence and toxicity characteristics. These pesticides cause neurological damage, endocrine disorders, and have acute and chronic health effects. Hence contamination of the environment with organochlorine pesticides drastically affects the ecosystem.

Can organochlorine affect the brain?

(13) The brain is particularly vulnerable to their effects as it is rich in lipids and has a low capacity for detoxification. Thus, OCs have been implicated in the development of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD).

Are organochlorines carcinogen?

Organochlorine pesticides (OCPs) are persistent organic pollutants (POPs) that have received worldwide attention due to their mutagenic, teratogenic, or carcinogenic characteristics and their resistance to degradation in the environment.

Can DDT cause Parkinson’s?

Researchers found that among men exposed to pesticides such as DDT, carriers of the gene variants were three and a half times more likely to develop Parkinson’s than those with the normal version of the gene.

Who made dieldrin?

J. Hyman & Co
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Dieldrin is an organochloride originally produced in 1948 by J. Hyman & Co, Denver, as an insecticide. Dieldrin is closely related to aldrin, which reacts further to form dieldrin.

What are the signs and symptoms of organochlorine toxicity?

Central nervous system (CNS) excitation and depression are the primary effects observed in acute organochlorine toxicity; therefore, the patient may appear agitated, lethargic, intoxicated, or may even be unconscious. Initial euphoria with auditory or visual hallucinations and perceptual disturbances are common in the setting of acute toxicity.

What are the CNS effects of organochlorine pesticides?

The toxicity of organochlorine (OC) pesticides varies according to their molecular size, volatility, and effects on the central nervous system (CNS). In general, they cause either CNS depression or stimulation, depending upon the agent and dose.

What is an organochlorine?

Table 1gives a comprehensive classification of pesticides based on their chemical nature. Among the various classes of pesticides, organochlorines and organophosphates are widely used. Organochlorines are known for their high persistence and toxicity characteristics.

How do organochlorines cause seizures?

Organochlorines lower the seizure threshold, which may precipitate seizure activity. Strong external stimuli and reflex hyperexcitability may precipitate muscle fasciculations and tonic spasms, which may evolve into seizures.