Can fibrous dysplasia become malignant?

It is very rare for areas of fibrous dysplasia to become malignant or cancerous. This occurs in less than 1% of patients and is more likely to happen in patients with the polyostotic form of the condition or in patients with McCune-Albright syndrome.

Is McCune-Albright syndrome malignant?

Malignant transformation of fibrous dysplasia lesions has been reported in patients with fibrous dysplasia/McCune-Albright syndrome (FD/MAS). Recently, we have observed an increased risk for breast cancer.

Can fibrous dysplasia come back?

However, lesions may grow again during pregnancy. The gene mutation associated with fibrous dysplasia occurs after conception, in the early stages of fetal development. Therefore, the mutation isn’t inherited from your parents, and you can’t pass it on to your children.

How is fibrous dysplasia treated?

Medications. Osteoporosis medications called bisphosphonates help prevent bone loss by decreasing the activity of cells that normally dissolve bone. Some studies suggest that bisphosphonates may strengthen bones affected by fibrous dysplasia and may relieve bone pain.

Is McCune-Albright syndrome curable?

Treatment is unique for each person diagnosed with McCune-Albright syndrome. There isn’t a cure for the condition and treatment aims to reduce symptoms. Treatment could include: Medicine to treat bone growth symptoms like bisphosphonates, which reduce the risk of bone fractures.

What happens in McCune-Albright syndrome?

Description. McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues. People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia.

Does fibrous dysplasia affect life expectancy?

Fibrous dysplasia is a rare bone disorder, commonly associated with pain, deformity and fractures, which may significantly impact on quality of life.

Can fibrous dysplasia be reversed?

Although fibrous dysplasia is a genetic disorder, it’s caused by a gene mutation that’s not passed from parent to child. There’s no cure for the disorder. Treatment, which may include surgery, focuses on relieving pain and repairing or stabilizing bones.

What is the prevalence of malignant transformation of fibrous dysplasia?

Malignant transformation of fibrous dysplasia (FD) is rare ( 1 – 4 ). It can occur in monostotic and polyostotic FD, with a frequency of <1% among all FD ( 2 ).

What is the pathophysiology of osteosarcoma from fibrous dysplasia?

Secondary osteosarcoma from fibrous dysplasia (FD) is very rare. The etiology of FD is linked to activating missense mutations of the guanine nucleotide‑binding protein α‑subunit (GNAS) gene, which encodes the stimulatory α subunit of the G protein (Gsα) and is located at chromosome 20q13.

What is fibrous dysplasia?

General Discussion. Fibrous dysplasia (FD) is a rare bone disorder. Bone affected by this disorder is replaced by abnormal scar-like (fibrous) connective tissue. This abnormal fibrous tissue weakens the bone, making it abnormally fragile and prone to fracture. Pain may occur in the affected areas.

What is the difference between monostotic and polyostotic FD?

FD may only affect one solitary bone (monostotic disease) or the disorder can be widespread, affecting multiple bones throughout the body (polyostotic disease). The severity of the disorder can vary greatly from one person to another.