Does Depakote cause low platelet count?

Does Depakote cause low platelet count?

In the studies with a larger sample size (> 150 subjects), thrombocytopenia occurred in 12–18% of subjects receiving treatment with valproate. Advanced age, female gender, and high doses were found to be risk factors for the development of thrombocytopenia during treatment with valproate.

Can divalproex cause low platelets?

Of these, 17.7% of patients experienced at least one episode of thrombocytopenia (platelet count < or = 100,000/microl) after exposure to divalproex sodium. A significant negative correlation was found between VPA levels and platelet counts. Women were significantly more likely to develop thrombocytopenia.

What medications cause platelets to drop?

Certain medications can reduce the number of platelets in your blood. Sometimes a drug confuses the immune system and causes it to destroy platelets. Examples include heparin, quinine, sulfa-containing antibiotics and anticonvulsants.

What medications affect platelet count?

The following are antiplatelet or anti-clotting drugs that reduce the platelet count: glycoprotein IIb/IIIa inhibitors, including abciximab, eptifibatide, and tirofiban. heparin….Over-the-counter (OTC) medications that can cause a low platelet count include:

  • acetaminophen.
  • ibuprofen.
  • naproxen.

What is a normal platelet count for a woman?

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia. You get your platelet number from a routine blood test called a complete blood count (CBC).

Can Depakote cause low white blood count?

Call you doctor to discuss the situation. Liver problems, which can be severe, may develop on Depakote, especially in the first six months of treatment. Problems with white blood cell count and blood platelets, which can also be severe, may also develop on this medication.

What drugs cause high platelets?

Drug-induced platelet dysfunction is an important cause of an acquired bleeding diathesis….Table II.

Drug class Drug
Phosphodiesterase inhibitors Milrinone
Other drugs Statins, fish oil
Anticoagulants Heparin
Antibiotics Beta-lactams, penicillins and cephalosporins

Can Depakote be taken before or after a platelet count?

Platelet count can be normalized by stopping the drug, and the identification of the responsible drug is important to prevent reexposure. 1 Thrombocytopenia can cause external bleeding in the form of petechiae, purpura on skin, bleeding from nose and mouth, or internal bleeding in any part of the body leading to a medical emergency.

What is the normal dose for Depakote?

The recommended starting dose is 500 mg once daily for 1 week, thereafter increasing to 1,000 mg once daily. Although doses other than 1,000 mg once daily of Depakote ER have not been evaluated in patients with migraine, the effective dose range of Depakote (divalproex sodium delayed-release tablets) in these patients is 500-1,000 mg/day.

Is Depakote bad for the liver?

Depakote is very bad for the liver, as you have experienced first hand. One of the best supplements to get the liver back in shape is N-Acetylcysteine. It’s what doctors give patients when their liver gets damaged by taking too much Tylenol. It’s available as a supplement.

Does Depakote cause loss of appetite?

What are the potential long-term effects of taking Depakote? Depakote can cause liver damage, and the risk is more likely to occur during the first 6 months of taking the medication. Signs might include nausea or vomiting, loss of appetite, abdominal pain, dark-colored urine, facial swelling, and yellowing of the skin or white of eyes.