What are E0771 cells?

The EO771 (also named E0771 or EO 771) murine mammary cancer cell line was originally isolated from a spontaneous tumour in C57BL/6 mouse. Although frequently used, this cell line remains poorly characterized.

Is E0771 triple negative?

Despite their isolation in the late 1940s, characterization of hormonal receptors and classification of EO771 line remains controversial. Indeed, its classification diverges according to the authors, which is considered as triple negative in 10 publications6, 12, 16-23 and as ERα+ in 19 publications.

What are EMT6 cells?

Description. EMT6 (ATCC® CRL-2755™) is a murine mammary carcinoma cell line derived from a transplanted hyperplastic alveolar nodule of a BALB/c mouse1. In syngeneic mice, EMT6 cells form tumors and spontaneous metastases, primarily to the lungs2,3.

What is MC38?

MC38 (Corbett el al., Can Res, 1975) is a murine colon adenocarcinoma cell line from a C57BL/6 mouse. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post implantation into syngeneic C57BL/6 mice or immunocompromised mice.

Is carcinoma serious?

Squamous cell carcinoma of the skin is usually not life-threatening, though it can be aggressive. Untreated, squamous cell carcinoma of the skin can grow large or spread to other parts of your body, causing serious complications.

What are eo771 and e0771?

The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced under different names: EO771, EO 771, and E0771. The characteristics of the EO771 cells are well described but some data are contradictory.

What do we know about e0771 cell line?

The E0771 cell line is a spontaneously developing medullary breast adenocarcinoma from C57BL/6 mice. Parental E0771 is poorly metastatic when compared to 4T1 and has homozygous mutations in the Trp53 and KRAS genes. In this spotlight, we present data from our initial growth and efficacy studies with the E0771 model.

What is e0771 murine breast cancer?

E0771 murine breast cancer cell line adenocarcinoma cell line originally isolated as a spontaneous tumor from C57BL/6 mouse (Sugiura, K and Stock, C.C., 1952) and adapted for anti‐cancer drug testing by Sirotnak et al., 1984 New Premium Package! includes STR Authentication/Pathogen Tested

Can e0771 cells be used for preclinical studies of mammary adenocarcinoma?

Thus, a mouse syngeneic model of mammary adenocarcinoma can be used by orthotopic injection of EO771 (also named E0771 or EO 771) cells into C57BL/6 mice. These cells could be widely used for preclinical studies.