What is interferon and ribavirin?

Ribavirin is a synthetic antiviral nucleoside analogue. In the treatment of hepatitis C it works very successfully with interferon but not on its own. It was originally developed as an antiviral agent for diseases that cause respiratory problems.

Is ribavirin still used for HCV?

The use of ribavirin with interferon or peginterferon for the treatment of hepatitis C is no longer recommended due to the poor efficacy and high rate of adverse effects with this regimen. Currently, still plays a role on a limited basis in combination with some direct-acting antiviral agents and combinations.

Is ribavirin a direct-acting antiviral?

Ribavirin revisited in the era of direct-acting antiviral therapy for hepatitis C virus infection.

What makes a patient ribavirin ineligible?

**Ribavirin(RBV) ineligible/intolerance is defined as meeting one or more of the following criteria: Neutrophils <750 cells/mm3,results within the past month. Hemoglobin < 10g/dL, results within the past month. Platelets <50 000 cells/ mm3, results within the past month.

Does IFITM3 inhibit retrovirus replication?

Knockout IFITM3 increased influenza virus A replication and overexpression IFITM3 inhibits influenza virus A replication. In addition to replication competent influenza A virus, IFITM proteins were able to inhibit retrovirus based pseudotyped influenza A virus, indicating that IFITM protein inhibit influenza A…

How does interferon induce IFITM protein expression?

The type I and II interferon induce IFITM proteins expression significantly. IFITM proteins are involved in the physiological process of immune response signaling, germ cell maturation and development. The gene is induced by interferon and the protein forms part of the signaling pathway.

What is the role of interferon-induced cell membrane proteins (IFITM3) in stomatitis?

Feeley EM, et al. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 2011;7(10):e1002337. [PMC free article][PubMed] [Google Scholar] 13. Weidner JM, et al. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol.

What is interferon (IFN)?

IFN is a protein made by various cells of the immune system, including white blood cells. IFN is produced as a response to “foreign” cells including viruses, bacteria, parasites, and tumor cells. The name “interferon” comes from IFN’s ability to interfere with the multiplication of these foreign cells.