What is the meaning of small round blue cell tumors?

The appearance is that of small, round, primitive cells that stain blue with conventional staining techniques for biopsy analysis. The small round blue cell tumors include neuroblastoma, rhabdomyosarcoma, non-Hodgkin’s lymphoma, and the Ewing’s family of tumors.

Can tumors Be Blue?

Neuroblastoma is a classic “small round blue cell” tumor. Others include Ewing sarcoma, non-Hodgkin lymphoma, primitive neuroectodermal tumors, and rhabdomyosarcoma.

Are tumors round and smooth?

A soft tissue tumor grows, slowly or quickly, in the body, based on its etiology. Generally, soft tissue tumors grow in a round orientation, though some can grow more oval or sausage-shaped.

What do round cells mean?

Round cells, in general, exfoliate individually and have distinct cytoplasmic borders. They are usually round in shape with round to indented nuclei, and samples are moderately cellular.

Can Round cells be benign?

However, cells range in morphology from discrete round cells to epithelioid to spindled cells and these cells can be highly variable in both benign and malignant forms. If poorly granulated, these cells are easily mistaken for other tumor types.

What is a small round blue cell tumour?

WHAT IS A SMALL ROUND BLUE CELL TUMOUR ANYWAY? The spectrum of ‘small round blue cell’ neoplasms is broad, but within the sinonasal tract (SNT), tumours of the dispersed neuroendocrine cell system narrow to olfactory neuroblastoma (ONB), pituitary adenoma, melanoma, and neuroendocrine carcinoma.

What is small round cell neoplasm?

This group of neoplasms is characterized by small, round, relatively undifferentiated cells. Differential diagnosis of small round cell tumors is particularly difficult due to their undifferentiated or primitive character.

What are the characteristics of malignant small round cell tumors?

Malignant small round cell tumors (small blue cell malignancies) prototypically are composed of cells with round to oval nuclei, scant cytoplasm, and often extensive cellular dissociation. Scanning microscopy often shows a “sheet” of nuclei.

Can 5b14 Mab be used to diagnose small round cell tumours?

The 5B14 mAb represents an additional tool for the differential diagnosis of small round cell tumours and might be useful in identifying neuroblastoma patients at risk of relapse who may take advantage of more careful follow-up. Keywords: B7-H3, diagnosis, neuroblastoma, small round cell tumours Introduction